054 Extracellular MAVS associates with microvesicles that can actively trigger IFNβ production

Extracellular vesicles: Exosomes, microvesicles, and friends

Cells release into the extracellular environment diverse types of membrane vesicles of endosomal and plasma membrane origin called exosomes and microvesicles, respectively. These extracellular vesicles (EVs) represent an important mode of intercellular communication by serving as vehicles for transfer between cells of membrane and cytosolic proteins, lipids, and RNA. Deficiencies in our knowled...

Inflammasome Activity Associates with NLRP3 and Regulates Its The Mitochondrial Antiviral Protein MAVS

Cells that trigger fever.

Bacterial lipopolysaccharide (LPS) is recognized by several receptors, including the toll-like receptor (TLR) 4, on various cells. Among many biological responses to LPS is fever, an often polyphasic rise in body temperature that is thought to be mediated by prostaglandin (PG) E(2). Which receptors on which cells are linked to fever production is unknown. It is also unknown which cells produce ...

Microvesicles: mediators of extracellular communication during cancer progression.

Microvesicles are generated by the outward budding and fission of membrane vesicles from the cell surface. Recent studies suggest that microvesicle shedding is a highly regulated process that occurs in a spectrum of cell types and, more frequently, in tumor cells. Microvesicles have been widely detected in various biological fluids including peripheral blood, urine and ascitic fluids, and their...

Epididymosomes: Role of extracellular microvesicles in sperm maturation.

The spermatozoa of vertebrate species that practice internal fertilization have to transit along the epididymis after leaving the testis. This epididymis is a single, long convoluted tubule that links the testis to the vas deferens (1). During this transit, the male gametes acquire their fertilizing ability and their forward motility properties. Collectively, these modifications known as sperm ...